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Plateforme d'Ingénierie Cellulaire et Analyses des Protéines



TMT-based quantitatice proteomics analysis reveals differentially expressed proteins between different sources of hMSCs. Int. J. Mol. Sci. 2023, 24, 13544. 

The bovine uterine fluid proteome is more impacted by the stage of the estrous cycle than the proximity of the ovulating ovary in the periconception period. Theriogenology. 2023. 198: 332-343.


Impact of Rhamnolipids (RLs), Natural Defense Elicitors, on Shoot and Root Proteomes of Brassica napus by a Tandem Mass Tags (TMTs) Labeling Approach. Int. J. Mol. Sci. 2023, 24, 2390.


Altered protein pattern of human brain pericyte-derived small extracellular vesicles after treatment with pro-inflammatory cytokines. Analytics. Nantes, France. 5-9 Septembre 2022.


Etude de l’impact de l’utilisation de stimulateurs de défenses naturelles (SDN) sur la paroi chez le colza par une approche protéomique différentielle. Analytics. Nantes, France. 5-9 Septembre


A deep characterization of human brain pericyte-derived small extracellular vesicles and their protein composition once exposed to pro-inflammatory cytokines. ISEV Annual Meeting. Lyon, France. 25-29 Mai.


TMT-based quantitative proteomics analysis reveals differentially expressed proteins between different sources of hMSCs. 2nd Joint Meeting of Spanish, French and Portuguese, Villamoura, Portugal. 11-13 Mais 2022.



Astrogliosis and compensatory neurogenesis after the first ethanol binge drinking-like exposure in the adolescent rat. Alcohol Clin Exp Res. 46(2): 207-200.


Characterization of human pericyte-derived small extracellular vesicles. International Symposium on Signal Transduction at the Blood-Brain Barriers, 22-24 Septembre 2021. Bari, Italy


Evaluation of Placental Transfer and Tissue Distribution of cis- and Trans-Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model. Front Pediatr. 2021. 23;9:730383.


Physiological and Biochemical Traits of Two Major Arabidopsis Accessions, Col-0 and Ws, Under Salinity. Front Plant Sci. 2021. 12:639154.


A Tandem Mass Tags (TMTs) labeling approach highlights differences between the shoot proteome of two Arabidopsis thaliana ecotypes, Col-0 and Ws. Proteomics. 2021. 11-12:e2000293.



Acute pathophysiological myocardial changes following intra-cardiac electrical shocks using a proteomic approach in a sheep model. Nature Sci Rep. 2020 Nov 20;10(1):20252. 


The combination of a poly-caprolactone/nano-hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects. Journal of Tissue Engineering and Regenerative Medicine. 2020. 14(11):1570-1580.


An alginate-based hydrogel with a high angiogenic capacity and a high osteogenic potential. BioResearch Open Access. 2020. 9(1):174-182.


Functional validation of a new alginate-based hydrogel scaffold combined with mesenchymal stem cells in a rat hard palate cleft model. Plastic and Reconstructive Surgery, Global Open. 2020. 8(4):e2743.


An untargeted liquid chromatography-mass spectrometry-based workflow for the structural characterization of plant polyesters. Plant J. 2020. 102(6):1323-1339. 



Determination of maternal and foetal distribution of cis- and trans-permethrin isomers and their metabolites in pregnant rats by liquid chromatography tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem. 2019. 411(30):8043-8052.

Cytological Approaches Combined With Chemical Analysis Reveals the Layered Nature of Flax Mucilage. Front Plant Sci. 2019 10 (684):1-16.

Metabolic markers for the yield of lipophilic indole alkaloids in dried woad leaves (Isatis tinctoria L.). Phytochemistry. 2019. 163:89-98.

Urinary Metabolomics Profiles Associated to Bovine Meat Ingestion in Humans. Mol Nutr Food Res. 2019. 63(1):e1700834.

Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership. Sci Rep. 2019. 9(1):1175.

Activation of the calcium-sensing receptor in human valvular interstitial cells promotes calcification. J Mol Cell Cardiol. 2019 Feb 12;129:2-12.

The contribution of the SOS signaling pathway in the cell wall dynamics in Arabidopsis. Poster. 15th Cell Wall Meeting, Cambridge, Royaume-Uni. 7-12 Juillet 2019.

The mode of action of pectin methylesterases as a determinant of pectin structure, cell wall mechanics and growth. Communication orale. 15th Cell Wall Meeting, Cambridge, Royaume-Uni. 7-12 Juillet 2019.

The maize low-lignin mutant F2bm3 shows pleiotropic effects on photosynthetic and cell wall metabolism in response to chilling. Poster. 15th Cell Wall Meeting, Cambridge, Royaume-Uni. 7-12 Juillet 2019.

Développement d’une méthode simple et rapide pour quantifier les pyréthrinoïdes dans le méconium par une approche LC-MS/MS. Communication orale. Congrès Francophone sur les Sciences Séparatives et les couplages. Paris. 25-28 mars 2019.


IP3R3 silencing induced actin cytoskeletal reorganization through ARHGAP18/RhoA/mDia1/FAK pathway in breast cancer cell lines. Biochem Biophys Acta Mol Cell Res. 2018 Jul;1865(7):945-958.

Quantitative Proteomic studies in flax seed development: seed coat-embryo interaction. 67th ASMS Conference on Mass Spectrometry and Allied Topics. San Diego, USA. 2-6 Juin 2018.

Development and validation of an LC-MS/MS method for the determination of maternal and fetal tissue distribution of permethrin and its metabolites in pregnant rats. 13rd International Mass Spectrometry Conference. Florence, Italie. 26-31 Août 2018.

Defect in pectin acetylesterase (PAE) expression triggers changes in pectin remodeling enzymes activities with consequent effect on root development. Communication orale. ICAR Congress. 25-28 Juin 2018.



Phenylpropanoid profiling reveals a class of hydroxycinnamoyl glucaric acid conjugates in Isatis tinctoria leaves. Phytochemistry. 2017 144:127-140.

Structural and dynamical characterization of the pH-dependence of the pectin methylesterase-pectin methylesterase inhibitor complex. J Biol Chem. 2017 Dec 29;292(52):21538-21547.

Apolipoprotein(a) inhibits hepatitis C virus entry through interaction with infectious particles. Hepatology. 2017 Jun;65(6):1851-1864.

Combined Experimental and Computational Approaches Reveal Distinct pH Dependence of Pectin Methylesterase Inhibitors. Plant Physiol. 2017 Feb;173(2):1075-1093.

Identification of the water-soluble protein components with acidic and neutral pHi in peanuts and determination of their immunoreactivity and behavior under roasting. Curr. Trends in Immunology. 2017 18 : 29-41.

Etude transcriptomique et métabolomique de la graine de lin au cours de son développement : interactions tégument-embryon. Poster. 11ème Journées Réseau Français des Parois, Orléans, France. 27-29 Juin 2017.

Molecular dynamics simulations reveals pH-dependent inhibition of PMEs through the modulation of PME-PMEi interaction. Poster. 11ème Journées Réseau Français des Parois, Orléans, France. 27-29 Juin 2017.

Rôle des ploygalacturoanes (PGs), des enzymes de dégradation des pectines dans le remodelage de la paroi durant le développement racinaire chez Arabidopsis thaliana. Poster. 11ème Journées Réseau Français des Parois, Orléans, France. 27-29 Juin 2017.

Functionnal characterization of two Arabidopsis pectin acetylesterases AtPAE7 and AtPAE11 and their deletion mutants. Poster. 11ème Journées Réseau Français des Parois, Orléans, France. 27-29 Juin 2017.



The kinetics of angiotensin-I metabolism in human carotid atheroma: An emerging role for angiotensin (1-7). Vascul Pharmacol. 2016 Oct;85:50-56.

PME58 plays a role in pectin distribution during seed coat mucilage extrusion through homogalacturonan modification. J Exp Bot. 2016 Apr;67(8):2177-90.

Expression of the calcium-sensing receptor in monocytes from synovial fluid is increased in osteoarthritis. Joint Bone Spine. 2016 Jun 23. pii: S1297-319X.

Defect in the expression of a pectin methelesterase triggers compensation mechanisms with consequent effects on cell wall mechanics. Poster. 11ème Journées Réseau Français des Parois, Orléans. 27-29 Juin 2016.

Combined experimental and computational approaches reveal distinct pH-controlled inhibiting capacities of Arabidopsis Pectin Methylesterase Inhibitors (PMEIs). Communication orale. Congrès Société Françasie de Biologie Végétale, Angers, France. 6-8 Juillet 2016.

Disruption of an Arabidopsis pectin acetylesterase, AtPAE7, alters root elongation. Poster. 14th Cell Wall Meeting, Chania, Crète. 12-17 Juin 2016.

Mechanochemical regulation of the release of flax seed coat mucilage. Poster. 14th Cell Wall Meeting, Chania, Crète. 12-17 Juin 2016.



Increased tumor infiltration by mucosal-associated invariant T cells correlates with poor survival in colorectal cancer patients. Cancer Immunol Immunother. 2015 Dec;64(12):1601-8.

Radical scavenging, antioxidant, and cytotoxic activities of the methanolic extracts from different organs of Ternstroemia pringlei. Pak J Pharm Sci. 2015 28(6 Suppl):2279-84.

Tuning of Pectin Methylesterification: Pectin methylesterase inhibitor 7 modulates the processive activity of co-expressed pectin methylesterase 3 in a pH-dependent manner. J Biol Chem. 2015 Sep 18;290(38):23320-35.

Arabidopsis PME17 Activity can be Controlled by Pectin Methylesterase Inhibitor4. Plant Signal Behav. 2015;10(2):e983351.

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells. Cancer Lett. 2015. 356(2 Pt B):971-7.

Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells. Oncotarget. 2015. 6(21):18484-503.

Substrate specificity of plant and fungi pectin methylesterases: Identification of novel inhibitors of PMEs. Int J Biol Macromol. 2015. 81:681-91.

Scenarios of crack propagation in bast fibers: Combining experimental and finite element approaches. Composite Structures. 2015. 133: 667–678.

Calcitriol prevents in vitro vascular smooth muscle cell mineralization by regulating calcium-sensing receptor expression. Endocrinology. 2015. 156(6):1965-74.

Distinct Effects of Inorganic Phosphate on Cell Cycle and Apoptosis in Human Vascular Smooth Muscle Cells. J Cell Physiol. 2015. 230(2):347-55.

Phenotypic, Transcriptomic and Metabolomic analysis of the interactions between seed coat and embryo of flaxseed. Poster. 9ème Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique, Lille, France. 9-11 Juin 2015.

Down-regulation of Pectin Methylesterase 32 expression triggers compensatory mechanisms in Arabidopsis thaliana. Poster. International Conference on Arabidopsis Research, Paris, France. 5-9 Juillet 2015.



Arabidopsis pectin methylesterase 17 is co-expressed with and processed by SBT3.5, a subtilisin-like serine protease. Ann Bot. 2014. 114(6):1161-75.

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases. Clin Exp Immunol. 2014.176(2):266-74.

Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells. Immunol Cell Biol. 2014. 92(7):591-604.

Total calcium-sensing receptor expression in circulating monocytes is increased in rheumatoid arthritis patients with severe coronary artery calcification. Arthritis Res Ther. 2014. 16(5):412.

Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats. PLoS One. 2014. 9(7):e102217.

TLR9 Ligand (CpG Oligodeoxynucleotide) Induces CLL B-Cells to Differentiate into CD20(+) Antibody-Secreting Cells. Front Immunol. 2014. 16;5:292.

Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action. Cardiovasc Res. 2014. 101(2):256-65.

Impact of press fractioning on Pinot meunier grape juice composition. Communication orale. International Conference Wine Active Compounds, Beaune, France, Mars 2014.

Mass Spectrometry based metabolomic analysis of flax germinating seeds: Is there a remobilisation of the lignan macromolecule? Poster. 8ème Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique. Lyon, France, Mai 2014.

Use of 1H- NMR for the metabolomic study of flaxseed (Linum usitatissimum) in development. Poster. 8ème Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique, Lyon, France. 19-21 Mai 2014.

Expression of the chloride co-transporters KCC2 and NKCC1 in the hippocampus of adolescent rats after perinatal exposure to alcohol: An immunofluorescence study. Poster. 18th Annual Meeting of the LARC-Neuroscience. Octobre 2014.

Metabolomic analysis of the interactions between seed coat and embryo of flaxseed. Poster. 10ème journées du Réseau Français des Parois, Amiens, France. 7-9 Juillet 2014.

Control of hypocotyl growth by pectin methylesterases (PMEs) in Arabidopsis thaliana. Poster. 10ème journées du Réseau Français des Parois, France, Amiens. 7-9 Juillet 2014.

Pectin methylesterase inhibitors (PMEIs) are not all equal: new insights into the specificity of the interaction between pectin methylesterases (PME) and their inhibitors in Arabidopsis. Communication orale. Plant Cell Wall Biology Conference, Palm Cove, Australie. 27-31 Juillet 2014.

Implication of a PME gene in mucilage structuration of Arabidopsis thaliana seed. Communication orale. 10ème Congrès Réseau Français des Parois, Amiens, France, 7-9 Juillet 2014.

Implication des pectines methylesterases das la croissance et l’activité de ces enzymes par un inhibiteur spécifique chez A. thaliana. Communication orale. 10ème Congrès du Réseau Français des Parois, Amiens, France. 7-9 Juillet 2014.


Proteomics Analysis of Morphogenic Changes of Human Umbilical Vein Endothelial Cells Induced by a Phorbol-Ester Mimicking Angiogenesis. Journal of Integrated OMICS. 2013. Vol 3, No 2 (2013)

New proteins and protein species identified in human umbilical vein endothelial cells by Fourier transform ion cyclotron resonance-mass spectrometry. 2013. Natural Science 05(08):919-924

Determination and modulation of total and surface calcium-sensing receptor expression in monocytes in vivo and in vitro. PLoS One. 2013. 8(10): e74800.

Identification of SLAMF3 (CD229) as an Inhibitor of Hepatocellular Carcinoma Cell Proliferation and Tumour Progression. PLoS One. 2013. 8(12): e82918.

A combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitro. PLoS One. 2013. 8(3):e60370.

Evaluation of a metabolic profiling strategy using liquid chromatography LTQ Orbitrap mass spectrometry for the metabolic characterization of Isatis tinctoria L. leaf extracts. Communication orale. 7ème Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique. Amiens, France, Juin 2013.

A role for pectin methylesterases (PMEs) in dark grown hypocotyl elongation in Arabidopsis. Poster. 13th Cell Wall Meeting. Nantes, Juillet 2013.

Biochemical characterization of an Arabidopsis pectin methylesterase AtPME3 and a pectin methylesterase inhibitor. Poster. 13th Cell Wall Meeting. Nantes, Juillet 2013.

Pectins demethylesterification and seed development. Poster. 13th Cell Wall Meeting, Nantes, France. 7-12 Juillet 2013.

Regulation of pectin methylesterases (PMEs) by subtilases (SBTs) and pectin methylesterases inhibitors (PMEIs) during root growth. Poster. 13th Cell Wall Meeting, Nantes, Juillet 2013.

Characterisation of proteins used as wine fining agent by LC-MS analysis: application to yeast protein extract (YPE). Poster. In-vino-analytica-scientia-symposium (IVAS). Juillet 2013.



Inorganic phosphate accelerates the migration of vascular smooth muscle cells: evidence for the involvement of miR-223. PLoS One. 2012. 7(10): e47807.

Phénotypage métabolique de lins mutants, Linum usitatissimum, pour la voie des phénylpropanoïdes. Poster. Congrès du Réseau Francophone de Métabolomique et Fluxomique. Nantes, France, Mai 2012.

Flax seed coat mucilage: formation and carbohydrate composition. Poster. 7ème Congrès Société Française de Biologie Végétale, Grenoble, France, Juillet 2012.

New  fragmentation pathway of tetrahydroprotoberberine alkaloids determined following in vivo bioconversion of 6-13C labelled tyramine in Corydalis bracteata (Fumariaceae). Poster. 29èmes Journées Françaises de Spectrométrie de Masse, Orléans, France, Septembre 2012.

Investigation of glycoclusters designed for lectin recognition by Q-TOF and LTQ-Orbitrap ESI-MS. Communication orale. 29èmes Journées Françaises de Spectrométrie de Masse, Orléans, France, Septembre 2012.

Identification des protéines présentes dans le mucilage séminal de la graine de lin par une approche protéomique. Congrès de la Société Française d’Electrophorèse & Analyses Protéomiques, Rouen, France, Octobre 2012.



Formation et structure du mucilage chez le lin. Poster. Journées du Réseau Français des Parois.  Lille, France, Juin 2011.



Strontium ranelate decreases receptor activator of nuclear factor-kB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor. Mol Pharmacol. 2010. 78(4):569-76.

Implication of the calcium sensing receptor and the Phosphoinositigde 3-kinase/Akt pathway in the extracellular calcium-mediated migration of RAW 264.7 osteoclast precursor cells. Bone. 2010. 46(5):1416-23.

Distinct phenotypic features of two fibrocompetent liver cell types: the contribution of proteomic. Proteomics. 2010. (5) :1017-28.



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